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The origin of 1V-LSD:
1-Valeroyl-d-lysergic acid diethylamide, also known as 1V-LSD or Valerie, belongs to the lysergamide class of novel psychedelic substances. This compound is closely related to LSD (lysergic acid diethylamide) and 1P-LSD, and it is known to produce effects that are nearly identical to those of LSD. While its exact pharmacology is not fully understood, it is believed to be similar to LSD, which interacts with serotonin, dopamine, and norepinephrine receptors in the brain.
1V-LSD emerged as a research chemical, with its synthesis likely occurring around June or July of 2021. Its introduction coincided with the announcement of the German NpSG ban on 1cP-LSD.
According to user reports, the subjective effects of 1V-LSD closely mirror those of 1P-LSD and LSD. It is theorized that 1V-LSD acts as a prodrug for LSD, meaning it converts into LSD or a similar compound in the body. The chemical similarities it shares with LSD suggest that its effects profile is almost identical, with potential differences primarily in the rate of absorption and duration of action.
These subjective effects typically include experiences such as geometric visual hallucinations, distortions in the perception of time, enhanced introspection, and ego dissolution. Due to its classical psychedelic effects and relatively well-tolerated nature, 1V-LSD has gained popularity among some users of novel psychoactive substances, who sometimes use it interchangeably with LSD
How 1V-LSD works in the brain:
1V-LSD (1-Valeroyl-d-lysergic acid diethylamide) is structurally related to LSD (lysergic acid diethylamide), and it is believed to work in the brain in a manner similar to LSD due to their structural similarities. While the exact mechanism of action of 1V-LSD is not fully understood, it is thought to primarily affect serotonin receptors in the brain, particularly the 5-HT2A receptor subtype, which is commonly associated with the psychedelic effects of hallucinogens.
Here’s a simplified explanation of how 1V-LSD and LSD are thought to work in the brain:
- Serotonin Receptor Activation: Both 1V-LSD and LSD are considered partial agonists for serotonin receptors. This means that they can bind to and activate serotonin receptors but do so less effectively than serotonin itself. The activation of 5-HT2A receptors by these substances is believed to play a crucial role in their psychedelic effects.
- Neurotransmitter Release: Activation of serotonin receptors, particularly 5-HT2A, leads to changes in neurotransmitter release in the brain. This includes an increase in the release of serotonin, dopamine, and norepinephrine, which are neurotransmitters associated with mood, perception, and cognition.
- Altered Brain Connectivity: The changes in neurotransmitter levels and receptor activation caused by 1V-LSD and LSD can result in altered brain connectivity patterns. This altered connectivity can lead to changes in sensory perception, thought patterns, and emotions.
- Psychedelic Effects: The combination of altered neurotransmitter levels and receptor activation ultimately produces the characteristic psychedelic effects associated with 1V-LSD and LSD. These effects can include visual and auditory hallucinations, changes in perception of time, heightened introspection, and in some cases, a sense of ego dissolution or oneness with the universe.
It’s important to note that while 1V-LSD is structurally related to LSD and is believed to produce similar effects, the specific pharmacological properties and safety profile of 1V-LSD may not be as well-studied as those of LSD. Additionally, individual responses to these substances can vary widely, and their use can carry risks, including psychological and physiological effects, and potential legal consequences, depending on local regulations. Therefore, caution and responsible use are essential when dealing with substances of this nature.
Traditional and modern use of 1V-LSD:
1V-LSD (1-Valeroyl-d-lysergic acid diethylamide) is not a well-known or widely studied substance, and its specific uses are not well-established. However, it is believed to be structurally related to LSD (lysergic acid diethylamide) and may produce similar effects. LSD itself is a powerful hallucinogenic substance, and it has been used for various purposes, although primarily not for recreational use.
Some potential uses for LSD and substances like 1V-LSD include:
- Psychotherapy: In the mid-20th century, LSD was studied for its potential therapeutic benefits, particularly in psychotherapy. It was used in controlled settings to explore its effects on mental health conditions such as depression, anxiety, and post-traumatic stress disorder (PTSD). Research into the therapeutic use of LSD has seen a resurgence in recent years, although it is still highly regulated in most countries.
- Spiritual or Religious Practices: Some individuals have used hallucinogenic substances, including LSD, in the context of spiritual or religious rituals to induce altered states of consciousness and facilitate introspection and spiritual experiences.
- Scientific and Research Purposes: Psychedelic substances like LSD have been used in scientific and research contexts to study consciousness, perception, and the brain. Researchers have investigated their effects on cognition, creativity, and problem-solving.
It’s important to note that the use of substances like 1V-LSD can be associated with significant risks, including unpredictable and intense hallucinogenic experiences, psychological distress, and, in some cases, adverse physical effects. Additionally, the legal status of such substances varies by country and region, and their use may be illegal in many places.
Furthermore, the safety and efficacy of 1V-LSD specifically may not be well-documented due to its limited history and research. If you are considering the use of 1V-LSD or any similar substance, it is crucial to prioritize your safety, be aware of the legal implications, and seek guidance from qualified healthcare professionals if you have any underlying medical or psychological conditions.